A randomised trial on the therapeutic effectiveness of bronchoalveolar lavage under fiberoptic bronchoscopy in patients with severe lung infection living in the Tibetan plateau area

BACKGROUND People living in plateau areas are prone to upper respiratory tract infections and secondary lung infections. The current study aimed explore the effects of bronchoalveolar lavage under fiberoptic bronchoscope for treatment patients with severe pulmonary infection areas. METHODS 148 admitted intensive care unit Shigatse People's Hospital (Shigatse, Tibet Autonomous Region, China) between July 2019 January 2021 were enrolled. Patients randomly assigned observational group or control group. For all patients, basic clinical data including sex, age, body mass index (BMI), blood pressure, diabetes history, stroke presence absence chronic obstructive disease, (gram-positive bacterial infection, gram-negative fungal acute abscess), surgical postoperative inhalation injury. collected. received conventional treatment, bronchoscopy. Pearson's correlation was used analyze correlations bronchoscopy inflammatory factors levels. Logistic regression investigate effectiveness treatment. RESULTS Before no significant difference existed After parameters mechanics 2 groups significantly improved compared those before (P<0.05). At same time, group, higher than levels lower (all P<0.05). full adjustment BMI, diabetes, abscess, therapeutic increased by 23% (OR =1.23, 95% CI: 1.09-1.51, P=0.007). CONCLUSIONS who resident high altitude areas, treatments, can improve chest, lung, total dynamic compliance, as well reduce procalcitonin (PCT) transforming growth factor-β, thus increasing